Maternal exposure to perfluorooctanoic acid inhibits luteal function via oxidative stress and apoptosis in pregnant mice.

@article{Chen2017MaternalET,
  title={Maternal exposure to perfluorooctanoic acid inhibits luteal function via oxidative stress and apoptosis in pregnant mice.},
  author={Yilu Chen and L Zhou and Jingjie Xu and Lu Zhang and Mo Li and Xingxing Xie and Yajuan Xie and Dan Luo and Dalei Zhang and Xiaochun Yu and Bei Yang and Haibin Kuang},
  journal={Reproductive toxicology},
  year={2017},
  volume={69},
  pages={159-166}
}
Perfluorooctanoic acid (PFOA) is a synthetic perfluorinated compound, which has been reported to exert adverse effect on the pregnancy. However, whether it is associated with alteration of luteal function remains unknown. Mice were administered PFOA by gavage from gestational days (GD) 1-7 or 13. PFOA treatment did not significantly affect numbers of embryo implantation. Nevertheless, on GD 13, 10mg/kg PFOA treatment significantly increased numbers of resorbed embryo. Furthermore, PFOA exposure… CONTINUE READING