Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice

@article{Hatch2007MaternalEO,
  title={Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice},
  author={Tevis Hatch and Alwin A. H. A. Derijck and Peter D Black and Godfried W. van der Heijden and Peter de Boer and Yuri E. Dubrova},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={4720-4724}
}
The results of a number of recent studies show that mutation rates in the offspring of irradiated parents are substantially elevated, however, the effect of parental genotype on transgenerational instability remains poorly understood. Here, we have analysed the mutation frequency at an expanded simple tandem repeat (ESTR) locus in the germline and bone marrow of the first-generation male offspring of control and irradiated male mice. The frequency of ESTR mutation was studied in the offspring… CONTINUE READING

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