Maternal deprivation increases behavioural reactivity to stressful situations in adulthood: suppression by the CCK2 antagonist L365,260

  title={Maternal deprivation increases behavioural reactivity to stressful situations in adulthood: suppression by the CCK2 antagonist L365,260},
  author={Vincent Vazquez and S{\'e}verine Farley and Bruno Giros and Val{\'e}rie Daug{\'e}},
RationaleMaternal deprivation can result in long-term impairment of neuronal functions and in the development of long-lasting behavioural disorders.ObjectivesThis study analysed the effects of a selective cholecystokinin-2 (CCK2) antagonist, 3R-(+)-N-(2,3-dihydro-1methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3yl)-N′-(3-methyl phenyl) urea (L365,260), in anxiety- and stress-related behaviours of adult rats that were deprived (D) from their mother and littermates for 3 h everyday during 14 days… 
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