Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring.

@article{Pileggi2016MaternalCL,
  title={Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring.},
  author={Chantal Pileggi and Stephanie A Segovia and James F. Markworth and Clint Gray and Xiaoyuan D. Zhang and Amber M. Milan and Cameron J Mitchell and Matthew P G Barnett and Nicole C. Roy and Mark H. Vickers and Clare M. Reynolds and David Cameron-Smith},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2016},
  volume={310 5},
  pages={
          R432-9
        }
}
A high-saturated-fat diet (HFD) during pregnancy and lactation leads to metabolic disorders in offspring concomitant with increased adiposity and a proinflammatory phenotype in later life. During the fetal period, the impact of maternal diet on skeletal muscle development is poorly described, despite this tissue exerting a major influence on life-long metabolic health. This study investigated the effect of a maternal HFD on skeletal muscle anabolic, catabolic, and inflammatory signaling in… Expand
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