Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart.

@article{Zhang2007MaternalCA,
  title={Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart.},
  author={Hai-Tao Zhang and Agus Darwanto and Thomas A. Linkhart and Lawrence C. Sowers and Lubo Zhang},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 5},
  pages={1319-28}
}
Protein kinase Cepsilon (PKCepsilon) plays a pivotal role in cardioprotection during cardiac ischemia and reperfusion injury. Recent studies demonstrated that prenatal cocaine exposure caused a decrease in PKCepsilon expression and increased heart susceptibility to ischemic injury in adult offspring, suggesting an in utero programming of PKCepsilon gene expression pattern in the heart. The present investigation aimed to elucidate whether an epigenetic mechanism, DNA methylation, accounts for… CONTINUE READING

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