Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.

@article{Velzquez2013MaternalCS,
  title={Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.},
  author={Ram{\'o}n Vel{\'a}zquez and Jessica A. Ash and Brian E. Powers and Christy M. Kelley and Myla S Strawderman and Zoe I Luscher and Stephen D Ginsberg and Elliott J. Mufson and Barbara J. Strupp},
  journal={Neurobiology of disease},
  year={2013},
  volume={58},
  pages={92-101}
}
In addition to intellectual disability, individuals with Down syndrome (DS) exhibit dementia by the third or fourth decade of life, due to the early onset of neuropathological changes typical of Alzheimer's disease (AD). Deficient ontogenetic neurogenesis contributes to the brain hypoplasia and hypocellularity evident in fetuses and children with DS. A murine model of DS and AD (the Ts65Dn mouse) exhibits key features of these disorders, notably deficient ontogenetic neurogenesis, degeneration… CONTINUE READING