Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice

@article{Ash2014MaternalCS,
  title={Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice},
  author={Jessica A. Ash and Ram{\'o}n Vel{\'a}zquez and Christy M. Kelley and Brian E. Powers and Barbara J. Strupp},
  journal={Neurobiology of Disease},
  year={2014},
  volume={70},
  pages={32-42}
}
Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration. The present study tested the hypothesis that maternal choline supplementation (MCS) improves spatial mapping and protects against BFCN degeneration in the Ts65Dn mouse model of DS and AD. During pregnancy and lactation, dams were assigned to either a choline sufficient (1.1g/kg choline chloride) or choline… CONTINUE READING

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References

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Perinatal choline influences brain structure and function.

Nutrition reviews • 2006
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