Maternal cfDNA screening for Down syndrome--a cost sensitivity analysis.

@article{Cuckle2013MaternalCS,
  title={Maternal cfDNA screening for Down syndrome--a cost sensitivity analysis.},
  author={Howard Cuckle and Peter Benn and Eugene P Pergament},
  journal={Prenatal diagnosis},
  year={2013},
  volume={33 7},
  pages={
          636-42
        }
}
OBJECTIVE This study aimed to determine the principal factors contributing to the cost of avoiding a birth with Down syndrome by using cell-free DNA (cfDNA) to replace conventional screening. METHODS A range of unit costs were assigned to each item in the screening process. Detection rates were estimated by meta-analysis and modeling. The marginal cost associated with the detection of additional cases using cfDNA was estimated from the difference in average costs divided by the difference in… CONTINUE READING
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