Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.

  title={Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.},
  author={D Liu and Josie Diorio and Beth M. Tannenbaum and Christian Caldji and Darlene D. Francis and A Freedman and S. Sharma and D Pearson and Paul M. Plotsky and Michael J. Meaney},
  volume={277 5332},
Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic… 

Variations in maternal care in infancy regulate the development of stress reactivity

Prenatal stress and long-term consequences: implications of glucocorticoid hormones

Patterns of Weaning and Adult Response to Stress

  • C. Cook
  • Psychology, Biology
    Physiology & Behavior
  • 1999

Hypothalamo-Pituitary-Adrenocortical Axis Function and Hedonic Behavior in Adult Male and Female Rats Prenatally Stressed by Maternal Food Restriction

The present experiments failed to reveal a decrease in hedonic behavior in prenatally stressed rats, and observed changes in hormone and CRH mRNA levels indicate that the gestational stress used did not result in a depression-like state in adult offspring.

Chronic Leptin Administration in Developing Rats Reduces Stress Responsiveness Partly through Changes in Maternal Behavior

The results demonstrate that the leptin signal is functional during the early developmental period and that leptin can modulate the hormonal response to stress in young rats either by a direct effect on the HPA axis or indirectly through changing some aspects of maternal behavior.



Neonatal endotoxin exposure alters the development of the hypothalamic- pituitary-adrenal axis: early illness and later responsivity to stress

Investigation of the long-term consequences of neonatal endotoxin exposure on hypothalamic-pituitary-adrenal axis (HPA) function in Long-Evans rats found that exposure to gram-negative LPS in early life can alter the development of neural systems which govern endocrine responses to stress and may thereby predispose individuals to stress-related pathology.

Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion

Results suggest that individual differences in adult emotional status may be governed by early environmental factors; however, perinatal experiences are not effective in influencing adult memory capacity.

Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence

In the present studies, plasma ACTH responses to both restraint and ether stress were significantly greater in NH compared with H animals, suggesting that H and NH animals do not differ in glucocorticoid fast feedback.

Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat.

It was found that H animals secreted less ACTH and corticosterone during and following the termination of stress than did nonhandled (NH) controls, and H animals were more sensitive than NH animals to the inhibitory effects of either B or dexamethasone on stress-induced adrenocortical activity.

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

Two model systems for producing reversible glucocorticoid receptor depletion in the hippocampus are used and it is found that depletion of receptors without inducing cell loss results in corticosterone hypersecretion.

Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress

Comparisons with the effects of manipulation of glucocorticoid status, comparable analyses were carried out in separate groups of animals following adrenalectomy with and without corticosteroid replacement, suggesting that exposure to a novel environment can effect a decrease in CRF mRNA levels in the olfactory bulb.

Glucocorticoid feedback inhibition of adrenocorticotropic hormone secretagogue release. Relationship to corticosteroid receptor occupancy in various limbic sites.

Increased hippocampal corticosteroid receptor occupancy was associated with suppressed adrenocorticotropic hormone secretagogue concentrations and the 'shape' of the hippocampal type II receptor occupancy versus initial AVP concentration curve suggested a nonlinear, threshold type of relationship, implying tight hippocampal regulation of AVP secretion.