Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model.

@article{Grigsby2012MaternalAT,
  title={Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model.},
  author={Peta L Grigsby and Miles J. Novy and Drew W. Sadowsky and Sanne J. Gordijn and Mary C Long and Ed P. Acosta and Lynn B. Duffy and Ken B. Waites},
  journal={American journal of obstetrics and gynecology},
  year={2012},
  volume={207 6},
  pages={
          475.e1-475.e14
        }
}
OBJECTIVE We assessed the efficacy of a maternal multidose azithromycin (AZI) regimen, with and without antiinflammatory agents to delay preterm birth and to mitigate fetal lung injury associated with Ureaplasma parvum intraamniotic infection. STUDY DESIGN Long-term catheterized rhesus monkeys (n = 16) received intraamniotic inoculation of U parvum (10(7) colony-forming U/mL, serovar 1). After contraction onset, rhesus monkeys received no treatment (n = 6); AZI (12.5 mg/kg, every 12 h… CONTINUE READING
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