Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.

@article{Braunschweig2012MaternalAI,
  title={Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.},
  author={Daniel Braunschweig and M. Golub and Claire M. Koenig and Lihong Qi and Isaac N Pessah and Judy Van de Water and Robert F. Berman},
  journal={Journal of neuroimmunology},
  year={2012},
  volume={252 1-2},
  pages={56-65}
}
A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development… CONTINUE READING
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