Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome.

@article{WitschBaumgartner2004MaternalAE,
  title={Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome.},
  author={Martina Witsch-Baumgartner and Martin Gruber and H. G. Kraft and Massimiliano Rossi and Peter Clayton and Marisa L Giros and David W. Haas and Richard I Kelley and Małgorzata Krajewska-Walasek and Gerd Utermann},
  journal={Journal of medical genetics},
  year={2004},
  volume={41 8},
  pages={577-84}
}
BACKGROUND Smith-Lemli-Opitz syndrome (MIM 270400) is an autosomal recessive malformation and mental retardation syndrome that ranges in clinical severity from minimal dysmorphism and mild mental retardation to severe congenital anomalies and intrauterine death. Smith-Lemli-Opitz syndrome is caused by mutations in the Delta7 sterol-reductase gene (DHCR7; EC… CONTINUE READING