Maternal and perinatal magnesium restriction predisposes rat pups to insulin resistance and glucose intolerance.

@article{Venu2005MaternalAP,
  title={Maternal and perinatal magnesium restriction predisposes rat pups to insulin resistance and glucose intolerance.},
  author={Lagishetty Venu and Yedla Durga Kishore and Manchala Raghunath},
  journal={The Journal of nutrition},
  year={2005},
  volume={135 6},
  pages={
          1353-8
        }
}
According to the fetal programming hypothesis, impaired intrauterine development results in insulin resistance and associated metabolic disturbances. Recently, we reported increased body fat, a forerunner of insulin resistance, in the pups of mineral-restricted rat dams. To identify the causative mineral(s), the effect of magnesium restriction was assessed. Female weanling WNIN rats (n = 21) consumed ad libitum for 9 wk a 70% magnesium-restricted diet or were pair-fed a control (C) diet (n = 7… 
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