Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.

  title={Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.},
  author={K. Sitarek},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  volume={19 6},
  • K. Sitarek
  • Published 1999
  • Biology, Medicine
  • Teratogenesis, carcinogenesis, and mutagenesis
N-methylmorpholine, which is used as a catalyst in polyurethane foams producing, in solvents, stabilizing agents, and corrosion inhibitors, was administered to female rats by gavage at 100, 200, 600, and 900 mg/kg during organogenesis. It did not exhibit selective toxicity toward the developing conceptus. This compound administered to pregnant females was fetotoxic and teratogenic in the presence of maternal toxicity. N-methylmorpholine induced anophthalmia, internal hydrocephalus, and… Expand
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