Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

@article{Warrington2018MaternalAF,
  title={Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors},
  author={N. Warrington and R. Beaumont and M. Horikoshi and F. Day and {\O}. Helgeland and C. Laurin and J. Bacelis and Shouneng Peng and K. Hao and B. Feenstra and A. Wood and A. Mahajan and J. Tyrrell and N. Robertson and N. W. Rayner and Z. Qiao and Gunn-Helen {\O}iseth Moen and M. Vaudel and C. Marsit and Jia Chen and M. Nodzenski and T. Schnurr and M. Zafarmand and J. Bradfield and N. Grarup and M. Kooijman and R. Li-Gao and F. Geller and T. Ahluwalia and L. Paternoster and R. Rueedi and V. Huikari and J. Hottenga and L. Lyytik{\"a}inen and A. Cavadino and S. Metrustry and D. Cousminer and Y. Wu and E. Thiering and CA Wang and C. Have and N. Vilor-Tejedor and P. Joshi and J. Painter and I. Ntalla and R. Myhre and N. Pitk{\"a}nen and E. V. van Leeuwen and R. Joro and V. Lagou and R. Richmond and A. Espinosa and S. Barton and H. Inskip and J. Holloway and L. Santa-Marina and X. Estivill and W. Ang and J. Marsh and C. Reichetzeder and L. Marullo and B. Hocher and K. Lunetta and J. Murabito and C. Relton and M. Kogevinas and L. Chatzi and C. Allard and L. Bouchard and M. Hivert and Ge Zhang and L. Muglia and Jani Heikkinen and C. S. Morgen and A. V. van Kampen and B. V. van Schaik and F. Mentch and C. Langenberg and J. Luan and R. Scott and Jing Hua Zhao and G. Hemani and S. Ring and A. Bennett and Kyle J. Gaulton and J. Fern{\'a}ndez-Tajes and N. V. van Zuydam and C. Medina-Gomez and H. D. de Haan and F. Rosendaal and Z. Kutalik and P. Marques-Vidal and Shikta Das and G. Willemsen and H. Mbarek and M. M{\"u}ller-Nurasyid and M. Standl and E. V. Appel and C. E. Fonvig and C. Trier and C. E. V. van Beijsterveldt and M. Murcia and M. Bustamante and S. Bon{\`a}s-Guarch and D. Hougaard and J. Mercader and A. Linneberg and K. Schraut and P. Lind and S. Medland and B. Shields and B. Knight and Jin-Fang Chai and K. Panoutsopoulou and M. Bartels and F. S{\'a}nchez and J. Stokholm and D. Torrents and R. Vinding and S. Willems and M. Atalay and B. Chawes and P. Kovacs and I. Prokopenko and M. Tuke and H. Yaghootkar and K. Ruth and Samuel E. Jones and Po-Ru Loh and A. Murray and M. Weedon and A. Tönjes and M. Stumvoll and K. Michaelsen and A. Eloranta and T. Lakka and C. V. van Duijn and W. Kiess and A. K{\"o}rner and H. Niinikoski and K. Pahkala and O. Raitakari and B. Jacobsson and E. Zeggini and G. Dedoussis and Y. Teo and S. Saw and G. Montgomery and H. Campbell and James F. Wilson and T. Vrijkotte and M. Vrijheid and E. D. de Geus and M. Hayes and H. Kadarmideen and J. Holm and L. Beilin and C. Pennell and J. Heinrich and L. Adair and J. Borja and K. Mohlke and J. Eriksson and E. Widen and A. Hattersley and T. Spector and M. K{\"a}h{\"o}nen and J. Viikari and T. Lehtim{\"a}ki and D. Boomsma and S. Sebert and P. Vollenweider and T. S{\o}rensen and H. Bisgaard and K. B{\o}nnelykke and J. Murray and M. Melbye and E. Nohr and D. Mook-Kanamori and F. Rivadeneira and A. Hofman and J. Felix and V. Jaddoe and T. Hansen and C. Pisinger and A. Vaag and O. Pedersen and A. Uitterlinden and M. J{\"a}rvelin and C. Power and E. Hypp{\"o}nen and D. Scholtens and W. Lowe and G. Davey Smith and N. Timpson and A. Morris and N. Wareham and H. Hakonarson and S. Grant and T. Frayling and D. Lawlor and P. Nj{\o}lstad and S. Johansson and K. Ong and M. McCarthy and J. Perry and David M. Evans and R. Freathy},
  journal={bioRxiv},
  year={2018}
}
Birth weight (BW) variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. These associations have been proposed to reflect the lifelong consequences of an adverse intrauterine environment. In earlier work, we demonstrated that much of the negative correlation between BW and adult cardio-metabolic traits could instead be attributable to shared genetic effects. However, that work and other… Expand
Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight
Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets
Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile
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