Maternal and environmental factors influence the hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone infusion in offspring of mothers with or without mood disorders.

@article{Ronsaville2006MaternalAE,
  title={Maternal and environmental factors influence the hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone infusion in offspring of mothers with or without mood disorders.},
  author={Donna S. Ronsaville and Giovanna Municchi and Carolyn Laney and Giovanni Cizza and Stephanie E Meyer and Adam J Haim and Marian Radke-Yarrow and George Chrousos and Phillip W. Gold and Pedro E. Martinez},
  journal={Development and psychopathology},
  year={2006},
  volume={18 1},
  pages={173-94}
}
Individuals with melancholic major depression exhibit basal hypercortisolism and an attenuated ACTH response to exogenous corticotropin-releasing hormone (CRH) infusion. Given the greater incidence of depression in children of depressed parents, we examined the ACTH and cortisol responses to ovine CRH (oCRH) infusion in 63 adolescent offspring of mothers with major depression, bipolar illness, or no psychiatric illness. Psychiatric and observational assessments of these families had been… CONTINUE READING