Maternal and Zygotic aldh1a2 Activity Is Required for Pancreas Development in Zebrafish

@inproceedings{Alexa2009MaternalAZ,
  title={Maternal and Zygotic aldh1a2 Activity Is Required for Pancreas Development in Zebrafish},
  author={Kristen Alexa and S Choe and Nicolas Hirsch and Letitiah Etheridge and Elizabeth R Laver and Charles G Sagerstr{\"o}m},
  booktitle={PloS one},
  year={2009}
}
We have isolated and characterized a novel zebrafish pancreas mutant. Mutant embryos lack expression of isl1 and sst in the endocrine pancreas, but retain isl1 expression in the CNS. Non-endocrine endodermal gene expression is less affected in the mutant, with varying degrees of residual expression observed for pdx1, carbA, hhex, prox1, sid4, transferrin and ifabp. In addition, mutant embryos display a swollen pericardium and lack fin buds. Genetic mapping revealed a mutation resulting in a… CONTINUE READING
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