Maternal age effect: the enigma of Down syndrome and other trisomic conditions.

@article{Gaulden1992MaternalAE,
  title={Maternal age effect: the enigma of Down syndrome and other trisomic conditions.},
  author={Mary Esther Gaulden},
  journal={Mutation research},
  year={1992},
  volume={296 1-2},
  pages={69-88}
}
Aneuploidy is the most frequently observed chromosome abnormality in human liveborn, abortuses and oocytes. The only etiological factor that has been established is advanced maternal age for the occurrence of trisomies, particularly trisomy 21 which causes Down syndrome. The maternal age effect remains an enigma. Recent molecular data bearing on this question are reviewed as are the hypotheses that have been proposed linking nondisjunction and maternal age. Rationale is presented for a… CONTINUE READING

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