Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model.

@article{Keelan2014MaternalAO,
  title={Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model.},
  author={Jeffrey A Keelan and Matthew W Kemp and Matthew S. Payne and David Johnson and Sarah Jane Stock and Masatoshi Saito and Prabhavathi B Fernandes and John P. Newnham},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 1},
  pages={447-54}
}
Solithromycin (CEM-101) is a new antibiotic that is highly potent against Ureaplasma and Mycoplasma spp. and active against many other antibiotic-resistant organisms. We have explored the maternal-amniotic-fetal pharmacokinetics of CEM-101 in a pregnant sheep model to assess its potential for treating intrauterine and antenatal infection. Chronically catheterized pregnant ewes (n = 6 or 7) received either a single maternal intravenous (i.v.) infusion of CEM-101 (10 mg/kg of body weight), a… CONTINUE READING

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The fetal safety of macrolides

  • A Bahat Dinur, G Koren, +4 authors A. Levy
  • Antimicrob. Agents Chemother
  • 2013

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