Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs

@inproceedings{TvedenNyborg2012MaternalVC,
  title={Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs},
  author={Pernille Tveden-Nyborg and Lucile Vogt and Janne Gram Schjoldager and Natalie Jeannet and Stine Hasselholt and Maya Devi Paidi and Stephan Christen and Jens Lykkesfeldt},
  booktitle={PloS one},
  year={2012}
}
While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study investigates how prenatal VitC deficiency affects postnatal hippocampal development and if any such effect can be reversed by postnatal VitC repletion. Eighty pregnant Dunkin Hartley guinea pig dams… CONTINUE READING
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