Maternal Syphilis: An Independent Risk Factor for Mother to Infant Human Immunodeficiency Virus Transmission

  title={Maternal Syphilis: An Independent Risk Factor for Mother to Infant Human Immunodeficiency Virus Transmission},
  author={Aarti Kinikar and Nikhil Gupte and Jayalakshmi Narayan Bhat and Renu Bharadwaj and Vandana Kulkarni and Ramesh A. Bhosale and Katherine McIntire and Vidya Mave and Nishi Suryavanshi and Sandesh Patil and Robert C Bollinger and Amita Gupta},
  journal={Sexually Transmitted Diseases},
  pages={371 - 375}
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study. Maternal syphilis, diagnosed serologically using Venereal Disease Research Laboratory titer plus Treponema Pallidum Hemagglutination Assay, was associated with 2.5-fold greater risk. 
Maternal HIV and syphilis are not syndemic in Brazil: Hot spot analysis of the two epidemics
It is hypothesized that maternal HIV and syphilis are two distinct epidemics in Brazil, and there is a spatial cluster of maternal HIV in the South, while syphilis is increasing throughout the country, more recently on the coast.
Novel Biochemical Insights in the Cerebrospinal Fluid of Patients with Neurosyphilis Based on a Metabonomics Study
The metabolic study of CSF may provide a new way to explore the pathogenesis of neurosyphilis, and Bilirubin, l-histidine, prostaglandin E2, alpha-kamlolenic acid, and butyryl-l-carnitine and palmitoyl- l-c Carnitine were identified as novel potential biomarkers for neuroSyphilis.
Introdução: As doenças infecciosas e que podem ser transmitidas da mãe para o bebê têm característica de cronicidade, ou seja, são assintomáticas; as principais são as causadas pelo vírus da hepatite


Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi
Maternal syphilis is associated with IU and IP/PP HIV MTCT, and screening and early treatment of maternal syphilis during pregnancy may reduce pediatric HIV infections.
Maternal syphilis and vertical perinatal transmission of human immunodeficiency virus type‐1 infection
  • M. Lee, R. Hallmark, L. Frenkel, G. del Priore
  • Medicine, Biology
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 1998
Integrated prevention of mother-to-child transmission for human immunodeficiency virus, syphilis and hepatitis B virus in China
Integrated PMTCT services proved to be feasible and effective, and they are now part of the routine maternal and child health services provided to infected women in China.
Risk for perinatal HIV-1 transmission according to maternal immunologic, virologic, and placental factors.
Identifiable subgroups of HIV-1-infected women based on maternal and placental characteristics had between a 7% and 71% risk of perinatal HIV- 1 transmission, and not only the overall rate of transmission but the impact of different risk factors for transmission appear to vary over the course of HIV infection.
Postnatal transmission of human immunodeficiency virus type 1 from mother to infant.
A prospective cohort study in Kigali, Rwanda, of 212 mother—infant pairs who were seronegative for HIV-1 at delivery and after a mean follow-up of 16.6 months, 16 of the 212 mothers became seropositive for HIV in their infants, and one infant was excluded from the analysis because of a positive test on the blood sample obtained at birth.
Postnatal transmission of human immunodeficiency virus type 1 from mother to infant. A prospective cohort study in Kigali, Rwanda.
HIV-1 infection can be transmitted from mothers to infants during the postnatal period and colostrum and breast milk may be efficient routes for the transmission of HIV-1 from recently infected mothers to their infants.
Maternal Herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study
HSV-2 infection is common among HIV-1-positive women and is associated with an increased risk of intra-partum mother-to-child-transmission (MTCT) of HIV- 1, and more than 25% of intra -partum MTCT may be attributable to maternal HSV- 2 co-infection.
Syphilis in HIV-infected Mothers and Infants: Results from the NICHD/HPTN 040 Study
Syphilis continues to be a common co-infection in HIV-infected women and can facilitate in utero transmission of HIV to infants, especially in low- and middle-income countries where both diseases are common.
Maternal Malaria and Perinatal HIV Transmission, Western Kenya,
The interaction between placental malaria and MTCT appears to be variable and complex: placental mortality that is controlled at low density may cause an increase in broad-based immune responses that protect against MTCT; uncontrolled, high-density malaria may simultaneously disrupt placental architecture and generate substantial antigen stimulus to HIV replication and increase risk for MTCT.
Cost-effectiveness of Integrated Routine Offering of Prenatal HIV and Syphilis Screening in China
Given the increasing prevalence of syphilis and HIV among pregnant women in China, prenatal HIV screening programs that also include syphilis screening are likely to be substantially more cost-effective than HIV screening alone and prevent many more adverse pregnancy outcomes.