Maternal Separation in Rats Leads to Anxiety-Like Behavior and a Blunted ACTH Response and Altered Neurotransmitter Levels in Response to a Subsequent Stressor

@article{Daniels2004MaternalSI,
  title={Maternal Separation in Rats Leads to Anxiety-Like Behavior and a Blunted ACTH Response and Altered Neurotransmitter Levels in Response to a Subsequent Stressor},
  author={Willie M. U. Daniels and Charmaine Y. Pietersen and Machteld Elizabeth Carstens and Dan J. Stein},
  journal={Metabolic Brain Disease},
  year={2004},
  volume={19},
  pages={3-14}
}
Adverse early life experiences can have a negative impact on behavior later in life. We subjected rat pups to maternal separation and determined the effects thereof on adult behavior. We removed rat pups from their mothers for 3 h daily from postnatal days 2 to 14. While controls were reared normally on day 60, the behaviors of the rats were tested using the elevated plus-maze. Some rats were subsequently subjected to restraint stress for a 10-min period. Trunk blood was collected for basal, as… CONTINUE READING

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