Maternal SENP7 programs meiosis architecture and embryo survival in mouse.

  title={Maternal SENP7 programs meiosis architecture and embryo survival in mouse.},
  author={Chun-Jie Huang and D. Wu and Xiaofei Jiao and F. Khan and C. Xiong and X. Liu and J. Yang and Tailang Yin and Lijun Huo},
  journal={Biochimica et biophysica acta. Molecular cell research},
  volume={1864 7},
  • Chun-Jie Huang, D. Wu, +6 authors Lijun Huo
  • Published 2017
  • Biology, Medicine
  • Biochimica et biophysica acta. Molecular cell research
  • Understanding the mechanisms underlying abnormal egg production and pregnancy loss is significant for human fertility. SENP7, a SUMO poly-chain editing enzyme, has been regarded as a mitotic regulator of heterochromatin integrity and DNA repair. Herein, we report the roles of SENP7 in mammalian reproductive scenario. Mouse oocytes deficient in SENP7 experienced meiotic arrest at prophase I and metaphase I stages, causing a substantial decrease of mature eggs. Hyperaceylation and hypomethylation… CONTINUE READING
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