Objective: The role of abnormal lipid profile as a risk factor in pathology of pre-eclampsia is controversial. We investigated the relationship between early pregnancy plasma lipid concentrations and risk of severe pre-eclampsia. Methodology: It was a prospective cohort study, in which one thousand maternal blood samples were collected at first trimester of pregnancy. We selected 63 women who developed severe preeclampsia from the cohort and 280 normotensive as control group matched with pre-eclamptic group. Plasma lipid concentrations were measured enzymatically. Data was analyzed with student t-test, and Relative risk with 95% confidence interval was calculated. Results: The risk of severe preeclampsia among women with serum triglyceride level >175 mg/ dl was 13.14 fold the ones with serum triglyceride level <100 (95% CI 1.84-265.4). Conclusion: This study has showed that early pregnancy dyslipidemia is associated with an increased risk of severe pre-eclampsia.