Maternal Phenylketonuria Collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae.

@article{Rouse1997MaternalPC,
  title={Maternal Phenylketonuria Collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae.},
  author={Bobbye M Rouse and Colleen G. Azen and Richard Koch and Reuben K Matalon and William B. Hanley and Felix de la Cruz and Frederick Trefz and E. Gross Friedman and H. Shifrin},
  journal={American journal of medical genetics},
  year={1997},
  volume={69 1},
  pages={89-95}
}
Maternal phenylketonuria (PKU) in untreated women has resulted in offspring with microcephaly, mental retardation, congenital heart disease (CHD), and intrauterine growth retardation. The Maternal Phenylketonuria Collaborative Study (MPKUCS) was designed to determine the effect of dietary control of blood phenylalanine (Phe) during pregnancy in preventing damage to the fetus associated with untreated Maternal PKU. A cohort of offspring from MPKUS pregnancies was ascertained and examined to… CONTINUE READING
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