Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery

  title={Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery},
  author={R. Tyzio and R. Cossart and I. Khalilov and M. Minlebaev and C. H{\"u}bner and A. Represa and Y. Ben-Ari and R. Khazipov},
  pages={1788 - 1792}
  • R. Tyzio, R. Cossart, +5 authors R. Khazipov
  • Published 2006
  • Biology
  • Science
  • We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, γ-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were triggered by oxytocin, an essential maternal hormone for labor. In vivo administration of an oxytocin… CONTINUE READING
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