Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery

@article{Tyzio2006MaternalOT,
  title={Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery},
  author={R. Tyzio and R. Cossart and I. Khalilov and M. Minlebaev and C. H{\"u}bner and A. Represa and Y. Ben-Ari and R. Khazipov},
  journal={Science},
  year={2006},
  volume={314},
  pages={1788 - 1792}
}
We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, γ-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were triggered by oxytocin, an essential maternal hormone for labor. In vivo administration of an oxytocin… Expand
Response to Comment on "Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery"
TLDR
Results suggest that oxytocin in the rat fetal brain is mainly provided by the mother, and cortisol analog methylprednisolone did not modify GABA driving force and intracellular chloride concentration in 1-day-old rat hippocampal neurons. Expand
Comment on "Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery"
TLDR
A body of evidence supports the possibility that oxytocin is released from the fetal pituitary during delivery, not only from the mother, particularly under conditions of hypoxic stress. Expand
Does maternal oxytocin protect the fetal brain?
TLDR
The authors hypothesize that the oxytocin is derived from the maternal circulation, representing a novel form of communication between the brain of the mother and her offspring, and that this protects the fetal brain from hypoxic or hypoglycemic insult during delivery. Expand
Effects of oxytocin on GABA signalling in the foetal brain during delivery.
TLDR
In the immature rat hippocampal and neocortical neurons at birth, endogenous OXT induced a switch in the action of GABA from excitatory to inhibitory, suggesting that OXT plays important role in the preparation of the foetal brain to delivery. Expand
Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
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The data validate the amelioration observed with bumetanide and oxytocin and point to common pathways in a drug-induced and a genetic rodent model of autism. Expand
Oxytocin is neuroprotective against oxygen–glucose deprivation and reoxygenation in immature hippocampal cultures
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It is suggested that oxytocin exerts a prolonged neuroprotective action on fetal neurons by increasing susceptibility of the fetal brain to hypoxic-ischemic insults. Expand
Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons
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Data demonstrate a disturbed Cl− homeostasis following TH deficiency and point to a delayed onset of synaptic inhibition in rats and mice. Expand
Neurosteroids are excitatory in supraoptic neurons but inhibitory in the peripheral nervous system: it is all about oxytocin and progesterone receptors.
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It is demonstrated that the primary metabolite of progesterone, allopregnanolone (Allo), evoked a robust Ca(2+) influx in foetal hypothalamic neurons and in postnatal supraoptic nucleus (SON) neurons, and proposed that this rapid, reversible and dose-dependent phenomenon was mediated by membrane Proges receptors. Expand
Postnatal changes in somatic γ‐aminobutyric acid signalling in the rat hippocampus
TLDR
The postnatal excitatory‐to‐inhibitory switch in somatic GABA signalling is associated with a negative shift of the GABA reversal potential but without a hyperpolarizing switch in the polarity of GABA responses, suggesting that in adult CA3 pyramidal cells, somatics GABAergic inhibition takes place essentially through shunting rather than hyperPolarization. Expand
GABAergic transmission and neuronal network events during hippocampal development
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The available evidence suggests that GDPs are the in vitro counterparts of SPWs in the immature hippocampus, and that the functionally excitatory action of GABA during early development is facilitatory but not instructive. Expand
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