Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

@article{Cirulli2020MaternalOA,
  title={Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring},
  author={F. Cirulli and C. Musillo and A. Berry},
  journal={Neuroscience},
  year={2020},
  volume={447},
  pages={122-135}
}
Maternal obesity plays a key role in the health trajectory of the offspring. Although research on this topic has largely focused on the potential of this condition to increase the risk for child obesity, it is becoming more and more evident that it can also significantly impact cognitive function and mental health. The mechanisms underlying these effects are starting to be elucidated and point to the placenta as a critical organ that may mediate changes in the response to stress, immune… Expand
Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity
TLDR
Preclinical and clinical evidence is reviewed and possible underlying neurobiological mechanisms by which maternal overnutrition may perturb offspring cognitive function, affective state and psychosocial behaviour are summarized, with a focus on neuroinflammation; disrupted neuronal circuities and connectivity; and dysregulated brain hormones. Expand
High-fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats.
TLDR
Results indicate that the same metabolic and neuroendocrine effectors engaged by PNS are affected by metabolic challenges at adulthood, providing some mechanistic insight into the well-known comorbidity between mood and metabolic disorders. Expand
Exploring the evidence for epigenetic regulation of environmental influences on child health across generations
TLDR
This review highlights the current epidemiologic literature and supporting animal studies that describe intergenerational and transgenerational health effects of environmental exposures by epigenetic mechanisms and discusses the ethical, legal and social implications of epigenetic research in humans. Expand
Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm
TLDR
Evidence for disrupted placental processes and regulated at least in part via epigenetic mechanisms, as well as perinatal inflammation are highlighted, which may inform efforts to detect and prevent adverse outcomes in infants born extremely preterm. Expand
Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day
TLDR
Parental obesity exerts a programming influence on the development of the skeletal system of the offspring on the day of the weaning, which was reflected in the intensification of mineralization and increased bone strength. Expand
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations
Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence forExpand
Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done
TLDR
Current knowledge on the potential effects of curcumin on cognition is highlighted and new strategies to overcome current limitations in its use and improve its efficacy are focused on, with attention also on gender-driven differences. Expand
Childhood trauma and insulin-like growth factors in amniotic fluid An exploratory analysis of 79 women
TLDR
The presented data suggests that childhood trauma can affect endocrine measurements of the developing next generation, providing a mechanism by which adverse maternal life events are transmitted to the next generation. Expand
The weight of motherhood: Identifying obesity, gestational weight gain and physical activity level of Italian pregnant women
TLDR
Italian pregnant women have a low exercise level, but still over 80% achieved a total physical activity level ⩾150 min/week when adding occupational and commuting activities, and a wider range of physical activity such as domestic chore, occupational activity and active commuting may help pregnant women to meet the physical activity recommendations. Expand
Neonatal Sevoflurane Exposure Impairs Learning and Memory by the Hypermethylation of Hippocampal Synaptic Genes.
Sevoflurane anesthesia is widely used in pediatric patients. Clinical studies report memory impairment in those exposed to general anesthesia early in life. DNA methylation is essential for theExpand

References

SHOWING 1-10 OF 157 REFERENCES
Influence of maternal obesity on the long-term health of offspring.
TLDR
There is an urgent need for studies on causality, underlying mechanisms, and effective interventions to reverse the epidemic of obesity in women of childbearing age and to mitigate consequences for offspring. Expand
A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring
TLDR
Current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring are summarized. Expand
Maternal high-fat diet programming of the neuroendocrine system and behavior
TLDR
Evidence from epidemiological studies indicates that maternal obesity and metabolic complications increase the risk of offspring developing behavioral disorders such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and schizophrenia. Expand
Interactions between early life stress and metabolic stress in programming of mental and metabolic health
  • F. Cirulli
  • Psychology
  • Current Opinion in Behavioral Sciences
  • 2017
The long-term consequences of psychosocial and socioeconomic challenges are hardly distinguishable from those of inappropriate nutrition, suggesting the existence of common physiological pathwaysExpand
Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN
TLDR
It is hypothesized that maternal insulin resistance and reduced placental glucocorticoid catabolism, leading to oxidative stress, may damage the DNA, either in its structure (telomere shortening) or in its function (via epigenetic changes), resulting in altered gene expression/repair, disease during life, and pathological ageing. Expand
The role of maternal obesity in the risk of neuropsychiatric disorders
TLDR
Given the high rates of obesity in most developed nations, it is critical that the mechanisms by which maternal obesity programs offspring behavior are thoroughly characterized, which will be critical in the development of preventative strategies and therapeutic interventions. Expand
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
  • S. Bilbo, Verne Tsang
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2010
TLDR
There were marked changes in anxiety and spatial learning in SFD/TFD groups, and these effects were all observed in adulthood, even after the pups were placed on standard chow at weaning, suggesting these outcomes were programmed early in life. Expand
Developmental Programming in Response to Maternal Overnutrition
TLDR
It is vital to identify which maternal factor – be it the diet, diet-induced obesity or weight gain – and at which time during early development instigate the programmed phenotype. Expand
Early Life Programming and Neurodevelopmental Disorders
TLDR
Consideration of the early life programming and transcriptional regulation in adult exposures supports a critical need to understand epigenetic mechanisms as a critical determinant in disease predisposition. Expand
Maternal high-fat diet alters anxiety behavior and glucocorticoid signaling in adolescent offspring
TLDR
Adolescent animals perinatally exposed to HFD generally showed decreased anxiety behavior accompanied by a selective alteration in the expression of the glucocorticoid receptor and several downstream inflammatory genes in the hippocampus and amygdala, suggesting that adolescence constitutes an additional period when the effects of developmental programming may modify mental health trajectories. Expand
...
1
2
3
4
5
...