Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

  title={Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring},
  author={Francesca Cirulli and Chiara Musillo and Alessandra Berry},
Impact of maternal obesity on the cognitive function and mental health of the offspring: a systematic review
Globally, more than 20% of women of reproductive age are currently estimated to be obese. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and
Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity
Preclinical and clinical evidence is reviewed and possible underlying neurobiological mechanisms by which maternal overnutrition may perturb offspring cognitive function, affective state and psychosocial behaviour are summarized, with a focus on neuroinflammation; disrupted neuronal circuities and connectivity; and dysregulated brain hormones.
Exploring the evidence for epigenetic regulation of environmental influences on child health across generations
This review highlights the current epidemiologic literature and supporting animal studies that describe intergenerational and transgenerational health effects of environmental exposures by epigenetic mechanisms and discusses the ethical, legal and social implications of epigenetic research in humans.
High‐fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats
Results indicate that the same metabolic and neuroendocrine effectors engaged by PNS are affected by metabolic challenges at adulthood, providing some mechanistic insight into the well‐known comorbidity between mood and metabolic disorders.
Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm
Evidence for disrupted placental processes and regulated at least in part via epigenetic mechanisms, as well as perinatal inflammation are highlighted, which may inform efforts to detect and prevent adverse outcomes in infants born extremely preterm.
Early-Life Environment Influence on Late-Onset Alzheimer’s Disease
Animal models indicate that offspring exposed to early-life stress during gestation and/or lactation increase both AD lesions, lead to defects in synaptic plasticity and finally to cognitive impairments, offering thus future therapeutic opportunity to protect from AD development.
Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day
Parental obesity exerts a programming influence on the development of the skeletal system of the offspring on the day of the weaning, which was reflected in the intensification of mineralization and increased bone strength.
Maternal Obesity Programming of Perivascular Adipose Tissue and Associated Immune Cells: An Understudied Area With Few Answers and Many Questions
The maternal contribution of the interplay between obesity, PVAT disruption and CVD is focused on and the leukocyte/PVAT interaction is highlighted as a novel target to stem the tide of the current obesity epidemic and its secondary health consequences.


Influence of maternal obesity on the long-term health of offspring.
Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN
It is hypothesized that maternal insulin resistance and reduced placental glucocorticoid catabolism, leading to oxidative stress, may damage the DNA, either in its structure (telomere shortening) or in its function (via epigenetic changes), resulting in altered gene expression/repair, disease during life, and pathological ageing.
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
  • S. Bilbo, Verne Tsang
  • Biology, Psychology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2010
There were marked changes in anxiety and spatial learning in SFD/TFD groups, and these effects were all observed in adulthood, even after the pups were placed on standard chow at weaning, suggesting these outcomes were programmed early in life.
Developmental Programming in Response to Maternal Overnutrition
It is vital to identify which maternal factor – be it the diet, diet-induced obesity or weight gain – and at which time during early development instigate the programmed phenotype.
Obesity-associated biomarkers and executive function in children
Obesity-associated biomarkers that have shown associations with neurocognitive skills, specifically executive functioning skills, which have far-reaching implications for child development are reviewed.