Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City.

@article{Pilsner2010MaternalMG,
  title={Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City.},
  author={J. Richard Pilsner and Howard Hu and Robert Wright and Katarzyna Kordas and Adrienne S. Ettinger and Brisa N S{\'a}nchez and David E. Cantonwine and Alicia L Lazarus and Alejandra J Cantoral and Lourdes Schnaas and Martha M T{\'e}llez-Rojo and Mauricio Hern{\'a}ndez-{\'A}vila},
  journal={The American journal of clinical nutrition},
  year={2010},
  volume={92 1},
  pages={226-34}
}
BACKGROUND Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations. OBJECTIVE The objective of this study was to examine potential links between maternal and child MTHFR polymorphisms and child neurodevelopment in a… CONTINUE READING
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