Maternal Immunization Earlier in Pregnancy Maximizes Antibody Transfer and Expected Infant Seropositivity Against Pertussis

@inproceedings{Eberhardt2016MaternalIE,
  title={Maternal Immunization Earlier in Pregnancy Maximizes Antibody Transfer and Expected Infant Seropositivity Against Pertussis},
  author={Christiane Sigrid Eberhardt and G{\'e}raldine Blanchard-Rohner and Barbara Lema{\^i}tre and Meriem Boukrid and Christophe Combescure and V{\'e}ronique Othenin-Girard and Antonina Chilin and Jean Petre and Bego{\~n}a Martinez de Tejada and C. -A. Siegrist},
  booktitle={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2016}
}
BACKGROUND Maternal immunization against pertussis is currently recommended after the 26th gestational week (GW). Data on the optimal timing of maternal immunization are inconsistent. METHODS We conducted a prospective observational noninferiority study comparing the influence of second-trimester (GW 13-25) vs third-trimester (≥GW 26) tetanus-diphtheria-acellular pertussis (Tdap) immunization in pregnant women who delivered at term. Geometric mean concentrations (GMCs) of cord blood… CONTINUE READING
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