Maternal Cdx2 is dispensable for mouse development.

  title={Maternal Cdx2 is dispensable for mouse development.},
  author={Stephanie Blij and Tristan T. Frum and Aytekin Akyol and Eric R. Fearon and Amy Ralston},
  volume={139 21},
In many invertebrate and vertebrate species, cell fates are assigned through the cellular inheritance of differentially localized maternal determinants. Whether mammalian embryogenesis is also regulated by deterministic mechanisms is highly controversial. The caudal domain transcription factor CDX2 has been reported to act as a maternal determinant regulating cell fate decisions in mouse development. However, this finding is contentious because of reports that maternal Cdx2 is not essential for… CONTINUE READING