Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.


The purpose of this study was to develop a targeted combinatorial polymeric micelle system that can sequentially kill tumor vasculature and tumor cells and increase the anticancer efficacy. Toward this goal, αvβ3 integrin-targeting peptide (RGD) functionalized polymeric micelles (RFPMs) based on the use of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PLA… (More)
DOI: 10.1016/j.jconrel.2010.10.027