Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.

@article{Wang2011MaterializingSK,
  title={Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.},
  author={Yiguang Wang and Tingyuan Yang and Xun Wang and Wenbing Dai and Jiancheng Wang and Xuan Zhang and Zaiquan Li and Qiang Zhang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={149 3},
  pages={299-306}
}
The purpose of this study was to develop a targeted combinatorial polymeric micelle system that can sequentially kill tumor vasculature and tumor cells and increase the anticancer efficacy. Toward this goal, αvβ3 integrin-targeting peptide (RGD) functionalized polymeric micelles (RFPMs) based on the use of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PLA) was developed. Doxorubicin was conjugated to the biodegradable PEG-PLA micelle core, and combretastatin A4 was physically encapsulated into… CONTINUE READING

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