Material control of stem cell differentiation: challenges in nano-characterization.

  title={Material control of stem cell differentiation: challenges in nano-characterization.},
  author={P. C. P. Dave Dingal and Dennis E Discher},
  journal={Current opinion in biotechnology},
Recent experiments have revealed that stem cells respond to biophysical cues as well as numerous biochemical factors. Nanoscale properties at the cell-matrix interface that appear to affect adherent stem cells range from matrix elasticity to porosity-dependent matrix tethering and geometry of adhesive linkages. Some stem cells can also remodel their immediate environment to influence phenotype, but this depends on matrix-material properties such as covalent bonding and soft versus hard… CONTINUE READING

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