Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis.

@article{Tzur2006MatefinSUN1IA,
  title={Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis.},
  author={Yonatan B Tzur and Ayelet Margalit and Naomi Melamed-Book and Yosef Gruenbaum},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 36},
  pages={
          13397-402
        }
}
In Caenorhabditis elegans, the antiapoptotic protein CED-9 is localized at the mitochondria, where it binds the proapoptotic protein CED-4. Induction of apoptosis begins when the proapoptotic protein EGL-1 is expressed and binds CED-9. The binding of EGL-1 to CED-9 releases CED-4 from CED-9 and causes the activation of the caspase CED-3. Upon its release from CED-9, CED-4 rapidly translocates to the nuclear envelope (NE) in a CED-3-independent manner. However, the identity of the NE receptor… CONTINUE READING

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