Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia

@article{Aypar2019MatePS,
  title={Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia},
  author={Umut Aypar and Stephanie A. Smoley and Beth A. Pitel and Kathryn E. Pearce and Roman M. Ženka and George Vasmatzis and Sarah H. Johnson and James B. Smadbeck and Jess F Peterson and Katherine B Geiersbach and Daniel L. Van Dyke and Erik C. Thorland and Robert B Jenkins and Rhett P Ketterling and Patricia T Greipp and Hutton M Kearney and Nicole L. Hoppman and Linda B. Baughn},
  journal={European Journal of Haematology},
  year={2019},
  volume={102},
  pages={87 - 96}
}
Acute myeloid leukemia (AML) can be subtyped based on recurrent cytogenetic and molecular genetic abnormalities with diagnostic and prognostic significance. Although cytogenetic characterization classically involves conventional chromosome and/or fluorescence in situ hybridization (FISH) assays, limitations of these techniques include poor resolution and the inability to precisely identify breakpoints. 
Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma
Fluorescence in situ hybridization (FISH) is currently the gold-standard assay to detect recurrent genomic abnormalities of prognostic significance in multiple myeloma (MM). Since most translocations
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