Matching of trastuzumab (Herceptin) epitope mimics onto the surface of Her-2/neu--a new method of epitope definition.

@article{Riemer2005MatchingOT,
  title={Matching of trastuzumab (Herceptin) epitope mimics onto the surface of Her-2/neu--a new method of epitope definition.},
  author={Angelika B Riemer and Georg Kraml and Otto Scheiner and Christoph Carl Zielinski and Erika Jensen-Jarolim},
  journal={Molecular immunology},
  year={2005},
  volume={42 9},
  pages={1121-4}
}
As seen with the proto-oncogene Her-2/neu, antibodies targeting different parts of a receptor can have opposing effects. Depending on epitope specificity, in this case, tumor growth can be inhibited--but also enhanced. Therefore, the definition of molecular binding sites is of increasing importance in modern medicine. We here introduce a novel approach for binding site localization, utilizing information obtained by the phage display technique. This is a high throughput screening method for… CONTINUE READING

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