Matching mice to malignancy: molecular subgroups and models of medulloblastoma

  title={Matching mice to malignancy: molecular subgroups and models of medulloblastoma},
  author={Jasmine Lau and Christin Schmidt and Shirley L. Markant and Michael D. Taylor and Robert J Wechsler-Reya and William S. Weiss},
  journal={Child's Nervous System},
Medulloblastoma, the largest group of embryonal brain tumors, has historically been classified into five variants based on histopathology. More recently, epigenetic and transcriptional analyses of primary tumors have subclassified medulloblastoma into four to six subgroups, most of which are incongruous with histopathological classification. Improved stratification is required for prognosis and development of targeted treatment strategies, to maximize cure and minimize adverse effects. Several… CONTINUE READING
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