Matching cellular dimensions with molecular sizes

  title={Matching cellular dimensions with molecular sizes},
  author={Michael Reth},
  journal={Nature Immunology},
  • M. Reth
  • Published 1 August 2013
  • Biology
  • Nature Immunology
This Commentary discusses the spatial perception of receptors and their nanoscale organization at the surface of the lymphocyte membrane. 

Erratum: Matching cellular dimensions with molecular sizes

  • M. Reth
  • Medicine
    Nature Immunology
  • 2014
This data indicates that the receptor depicted would measure about 3 μm, compared with a resting B lymphocyte, with an average diameter of about 7μm, which is similar to that of a resting T lymphocyte.

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Transmembrane signaling: the joy of aggregation.

  • H. Metzger
  • Chemistry, Medicine
    Journal of immunology
  • 1992

From mosaic to patchwork: Matching lipids and proteins in membrane organization

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The data is reviewed in support of conformational changes in the TCR as the basic principle to transduce the activation signal to the cytoplasm and the incipient data suggesting cooperativity within nanoclusters.

Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton

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Signal initiation in T‐cell receptor microclusters

This work examines how lipid rafts, galectin lattices, and protein scaffolds contribute to the assembly, function, and fate of TCR microclusters within immune synapses and proposes a ‘mechanical segregation’ model of signal initiation in which cytoskeletal forces contribution to the lateral segregation of molecules and cytoskeleton scaffolds provide a template for microcluster assembly.

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The association of TCRs into nanoclusters can explain the enhanced kinetics of the pMHC–TCR interaction in two dimensional versus three dimensional systems, but also their existence calls for a revision of the TCR triggering models based on pM HC‐induced TCR clustering.

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

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