Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.

@article{Helenius2009Mat1IP,
  title={Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.},
  author={Katja Helenius and Ying Yang and Jukka S. Alasaari and Tomi P. M{\"a}kel{\"a}},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 2},
  pages={315-23}
}
Mammalian Cdk7, cyclin H, and Mat1 form the kinase submodule of transcription factor IIH (TFIIH) and have been considered ubiquitously expressed elements of the transcriptional machinery. Here we found that Mat1 and Cdk7 levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis, where activation of peroxisome proliferator-activated receptor gamma (PPARgamma) acts as a critical differentiation switch. Using both Mat1(-/-) mouse embryonic fibroblasts and Cdk7… CONTINUE READING