Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo.

@article{Azevedo2015MastoparanIA,
  title={Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo.},
  author={Ricardo Alexandre de Azevedo and Carlos R Figueiredo and Adilson Kleber Ferreira and Alisson Leonardo Matsuo and Mariana Hiromi Massaoka and N{\'a}talia Girola and Aline Vivian Vatti Auada and Camyla Fernandes Farias and Kerly F. M. Pasqualoto and Cec{\'i}lia Pessoa Rodrigues and Jos{\'e} Alexandre Marzag{\~a}o Barbuto and D{\'e}bora Levy and S{\'e}rgio Paulo Bydlowski and Paulo L de S{\'a}-Junior and Luiz R Travassos and Ivo Lebrun},
  journal={Peptides},
  year={2015},
  volume={68},
  pages={113-9}
}
Mastoparan is an α-helical and amphipathic tetradecapeptide obtained from the venom of the wasp Vespula lewisii. This peptide exhibits a wide variety of biological effects, including antimicrobial activity, increased histamine release from mast cells, induction of a potent mitochondrial permeability transition and tumor cell cytotoxicity. Here, the effects of mastoparan in malignant melanoma were studied using the murine model of B16F10-Nex2 cells. In vitro, mastoparan caused melanoma cell… CONTINUE READING

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