Mastocytosis: pathology, genetics, and current options for therapy.

@article{Valent2005MastocytosisPG,
  title={Mastocytosis: pathology, genetics, and current options for therapy.},
  author={Peter Valent and Cem Akin and Wolfgang R Sperr and Matthias Mayerhofer and Manuela F{\"o}dinger and Robert Fritsche-Polanz and Karl Sotlar and L. M. Escribano and Michel Arock and H P Horny and Dean D Metcalfe},
  journal={Leukemia & lymphoma},
  year={2005},
  volume={46 1},
  pages={
          35-48
        }
}
Mast cell disorders are defined by an abnormal accumulation of tissue mast cells (MCs) in one or more organ systems. Symptoms in mastocytosis result from MC-derived mediators and, less frequently, from destructive infiltration of MCs. Cutaneous mastocytosis (CM) is a benign disease of the skin and may regress spontaneously. Systemic mastocytosis (SM) is a persistent disease in which a somatic c-kit mutation at codon 816 is usually detectable in MCs and their progenitors. The clinical course in… CONTINUE READING
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