Masters and Servants of the Force: Focal Adhesion Size Controls Recruitment of α-Smooth Muscle Actin to Stress Fibers

@inproceedings{Goffin2005MastersAS,
  title={Masters and Servants of the Force: Focal Adhesion Size Controls Recruitment of α-Smooth Muscle Actin to Stress Fibers},
  author={J{\'e}r{\^o}me M. Goffin and Gabor Csucs and Jost Wendelin Lussi and Jean-Jacques Meister and Boris Hinz},
  year={2005}
}
Mechanical stress is a crucial factor for modulating fibroblasts into differentiated myofibroblasts, which are characterized by expression of α-smooth muscle actin (α-SMA). Incorporation of α-SMA into stress fibers generates high contractile activity and drives the formation of “supermature” focal adhesions (FA) that are considerably longer (6–30 μm) compared with “classical” FAs (2–6 μm) of α-SMA-negative fibroblasts. We here show that in turn, supermature FAs control myofibroblast… CONTINUE READING

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