Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

Abstract

Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master regulator of hematopoietic stem/progenitor cells GATA-2 was cloned almost 20 years ago, and elegant genetic analyses demonstrated its essential function to promote hematopoiesis. While certain GATA-2 target… (More)
DOI: 10.1093/nar/gks281

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