Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes*

@inproceedings{Hino2014MasterRF,
  title={Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes*},
  author={Kenta Hino and Atsushi Saito and Miori Kido and Soshi Kanemoto and Rie Asada and Tomoko Takai and Min Cui and Xiang Cui and Kazunori Imaizumi},
  booktitle={The Journal of biological chemistry},
  year={2014}
}
The endoplasmic reticulum (ER) stress transducer, box B-binding factor 2 human homolog on chromosome 7 (BBF2H7), is a basic leucine zipper (bZIP) transmembrane transcription factor. This molecule is activated in response to ER stress during chondrogenesis. The activated BBF2H7 accelerates cartilage matrix protein secretion through the up-regulation of Sec23a, which is responsible for protein transport from the ER to the Golgi apparatus and is a target of BBF2H7. In the present study, we… CONTINUE READING