Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype

@article{Friend1996MastCT,
  title={Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype},
  author={Daniel Friend and Namit Ghildyal and K Frank Austen and Michael F. Gurish and Ryoji Matsumoto and Richard L. Stevens},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={279 - 290}
}
Whether or not a nontransformed, mature mouse mast cell (MC) or its committed progenitor can change its granule protease phenotype during inflammatory responses, has not been determined. To address this issue, the granule morphology and protease content of the MC in the jejunum of BALB/c mice exposed to Trichinella spiralis were assessed during the course of the infection. Within 1 wk after helminth infection of the mice, increased numbers of MC appeared in the crypts at the base of the villi… CONTINUE READING

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