Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication

@article{Moyer2004MastCP,
  title={Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication},
  author={Kurtis E. Moyer and Gregory C. Saggers and H. Paul Ehrlich},
  journal={Wound Repair and Regeneration},
  year={2004},
  volume={12}
}
The release of mast cell granules is commonly associated with inflammation and fibrosis. However, does direct communication between mast cells and fibroblasts through gap junction intercellular communication (GJIC) occur? Fibroblast populated collagen lattice (FPCL) cast with mast cells show enhanced lattice contraction. Do released granules or GJIC between mast cells and fibroblasts promote enhanced lattice contraction? Mast cells preloaded with a fluorescent dye that readily passes through… 

Rat Mast Cells Enhance Fibroblast Proliferation and Fibroblast-Populated Collagen Lattice Contraction through Gap Junctional Intercellular Communications

Heterocellular gap junctional intercellular communications with mast cells increase in fibro Blast proliferation and fibroblast PCL contraction, two hypertrophic scar fibroblasts activities.

Through Gap Junction Communications, Co-Cultured Mast Cells and Fibroblasts Generate Fibroblast Activities Allied with Hypertrophic Scarring

Eliminating the mast cell or its gap junctional intercellular communications with fibroblasts may be a possible approach in preventing hypertrophic scarring or reducing fibrotic conditions.

Rat mast cells communicate with fibroblasts via gap junction intercellular communications

It is proposed that GJIC between granulation tissue fibroblasts and MCs can modulate some aspects of wound repair and fibrosis.

MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.

It is demonstrated that activation of primary human mast cells with IgE receptor cross-linking, or activation of HMC-1 with C5a, enhanced contractility of human lung fibroblasts in a three-dimensional collagen lattice system.

Premature Collagen Fibril Formation, Fibroblast-Mast Cell Interactions and Mast Cell-Mediated Phagocytosis of Collagen in Keloids

The observation of early formation in keloid tissue of premature insoluble collagen fibrils supports previous studies that enzymes such as procollagen C-proteinase are important early therapeutic targets.

Role of Intercellular Interactions between Mast Cells and Gingival Fibroblasts in Mediating Inflammation

It is concluded that mast cells adhere to fibroblasts and promote IL-8 secretion, thereby enhancing neutrophil chemotaxis and possibly the perpetuation of the inflammatory response.

Intercellular interactions between mast cells and stromal fibroblasts obtained from canine cutaneous mast cell tumours

The establishment of primary cocultures of neoplastic mast cells from canine cutaneous MCTs and cancer-associated fibroblasts and the use of conditioned medium from co-cultured cells led to a significantly higher tumoral mast cell viability when in monoculture.

A Snapshot of Direct Cell-Cell Communications in Wound Healing and Scarring.

  • H. Ehrlich
  • Biology, Medicine
    Advances in wound care
  • 2013
GJIC between mast cells and fibroblasts during the remodeling phase of repair may explain how mast cells promote excessive scarring and the association of Cx with microtubules altering TGF-β signaling presents a new target for improving the quality of repair.

Cell-populated collagen lattice contraction model for the investigation of fibroblast collagen interactions.

In this chapter methods are described for manufacturing collagen lattices, which assess the three forces involved in compacting and/or organizing collagen fibrils into thicker collagen fibers.
...

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