Mast cells promote atherosclerosis by releasing proinflammatory cytokines

  title={Mast cells promote atherosclerosis by releasing proinflammatory cytokines},
  author={Jiusong Sun and Galina K Sukhova and Paul J Wolters and Min Yang and Shiro Kitamoto and P. Scott Libby and Lindsey A MacFarlane and Jon Mallen-St Clair and G P Shi},
  journal={Nature Medicine},
Mast cells contribute importantly to allergic and innate immune responses by releasing various preformed and newly synthesized mediators. Previous studies have shown mast cell accumulation in human atherosclerotic lesions. This report establishes the direct participation of mast cells in atherogenesis in low-density lipoprotein receptor–deficient (Ldlr−/−) mice. Atheromata from compound mutant Ldlr−/− KitW-sh/W-sh mice showed decreased lesion size, lipid deposition, T-cell and macrophage… CONTINUE READING
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