Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation.

  title={Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation.},
  author={Kei Ikeda and Hiroshi Nakajima and Kotaro Suzuki and Shin-ichiro Kagami and Koichi Hirose and Akira Suto and Yasushi Saito and Itsuo Iwamoto},
  volume={101 9},
Interleukin-25 (IL-25) is a recently described T helper 2 (T(H)2) cell-derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T-cell population. Here, we show that mast cells are also potent IL-25-producing cells. When bone marrow-derived mast cells were stimulated by immunoglobulin E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent manner, and the levels of IL-25 mRNA were comparable with… CONTINUE READING
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