Mast cells in psoriatic skin are strongly positive for interferon-gamma.

@article{Ackermann1999MastCI,
  title={Mast cells in psoriatic skin are strongly positive for interferon-gamma.},
  author={Luc Ackermann and Ilkka Tapani Harvima and Jukka Pelkonen and V Ritam{\"a}ki-Salo and Anita Naukkarinen and Rauno J. Harvima and Maija Horsmanheimo},
  journal={The British journal of dermatology},
  year={1999},
  volume={140 4},
  pages={
          624-33
        }
}
The increased number and early activation of cutaneous mast cells is a typical feature of psoriatic inflammation. Interferon-gamma (IFN-gamma) is believed to be one of the important mediators in the cytokine cascade of psoriasis. Human mast cells have been previously reported to release various cytokines upon stimulation including interleukin (IL) -4, IL-5, IL-6, IL-8, IL-13 and tumour necrosis factor-alpha. Here we report that human mast cells synthesize also IFN-gamma at mRNA and protein… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Relationship between Mast Cells and Autoimmune Diseases

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Skin Immunity

  • Archivum Immunologiae et Therapiae Experimentalis
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND