Mast cells in psoriatic skin are strongly positive for interferon‐gamma

@article{Ackermann1999MastCI,
  title={Mast cells in psoriatic skin are strongly positive for interferon‐gamma},
  author={Ackermann and Harvima and Pelkonen and RITAM{\"A}KI‐SALO and Naukkarinen and Horsmanheimo},
  journal={British Journal of Dermatology},
  year={1999},
  volume={140}
}
The increased number and early activation of cutaneous mast cells is a typical feature of psoriatic inflammation. Interferon‐gamma (IFN‐γ) is believed to be one of the important mediators in the cytokine cascade of psoriasis. Human mast cells have been previously reported to release various cytokines upon stimulation including interleukin (IL) ‐4, IL‐5, IL‐6, IL‐8, IL‐13 and tumour necrosis factor‐alpha. Here we report that human mast cells synthesize also IFN‐γ at mRNA and protein level and… Expand
80 Citations
A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin
  • 76
  • PDF
Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis.
  • 112
Scanning the Immunopathogenesis of Psoriasis
  • 79
  • PDF
Psoriatic arthritis under the influence of IFNγ.
  • 1
Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion.
  • 129
  • PDF
Immunopathogenesis and role of T cells in psoriasis.
  • 179
Is there a role for mast cells in psoriasis?
  • 98
  • PDF
Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation.
  • 68
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 56 REFERENCES
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.
  • 781
  • PDF
In situ localization of interferons in psoriatic lesions
  • 36
  • PDF
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.
  • 434
An Altered Response by Psoriatic Keratinocytes to Gamma Interferon
  • 59
Constitutive and Inducible Cytokine mRNA Expression in the Human Mast Cell Line HMC‐1
  • 58
...
1
2
3
4
5
...