Mast cells in photodamaged skin: what is their role in skin cancer?

  title={Mast cells in photodamaged skin: what is their role in skin cancer?},
  author={Michele A. Grimbaldeston and John J. Finlay-Jones and Prue H Hart},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  volume={5 2},
In this review, changes that we have observed in the prevalence of mast cells in human sun-exposed skin, and their potential immunoregulatory role, are discussed. More specifically, in a study of Australian volunteers, the prevalence of dermal mast cells was increased in back-of-hand skin, anecdotally the most sun-exposed site of the body, but not in skin from buttock, inner arm or shoulder. By histological analysis of back-of-hand skin, there was a significant correlation between dermal mast… CONTINUE READING

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