Mast cells enhance contraction of three-dimensional collagen lattices by fibroblasts by cell-cell interaction: role of stem cell factor/c-kit.

@article{Yamamoto2000MastCE,
  title={Mast cells enhance contraction of three-dimensional collagen lattices by fibroblasts by cell-cell interaction: role of stem cell factor/c-kit.},
  author={Toshiyuki Yamamoto and Karin Hartmann and Beate Eckes and Thomas Krieg},
  journal={Immunology},
  year={2000},
  volume={99 3},
  pages={435-9}
}
Reorganization of the extracellular matrix is important in many biological and pathophysiological processes, including tissue remodelling, wound healing, or cancer metastasis. The ability of cultured fibroblasts to reorganize and contract three-dimensional type I collagen gels is regarded as an in vitro model for this process. In tissue fibrosis, complex interactions among fibroblasts, inflammatory cells and the extracellular matrix are taking place. Mast cells have often been discussed to play… CONTINUE READING

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